PMID- 21349861 OWN - NLM STAT- MEDLINE VI - 27 IP - 8 TI - Improved structure, function and compatibility for CellProfiler: modular high-throughput image analysis software. PG - 1179-80 LA - eng PT - Journal Article PT - Research Support, N.I.H., Extramural PL - England TA - Bioinformatics JT - Bioinformatics (Oxford, England) JID - 9808944 IS - 1367-4811 (Electronic) LID - 10.1093/bioinformatics/btr095 [doi] FAU - Kamentsky, Lee AU - Kamentsky L AD - Imaging Platform, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. FAU - Jones, Thouis R AU - Jones TR FAU - Fraser, Adam AU - Fraser A FAU - Bray, Mark-Anthony AU - Bray MA FAU - Logan, David J AU - Logan DJ FAU - Madden, Katherine L AU - Madden KL FAU - Ljosa, Vebjorn AU - Ljosa V FAU - Rueden, Curtis AU - Rueden C FAU - Eliceiri, Kevin W AU - Eliceiri KW FAU - Carpenter, Anne E AU - Carpenter AE IS - 1367-4803 (Linking) SB - IM MH - Algorithms MH - High-Throughput Screening Assays MH - Image Processing, Computer-Assisted/*methods MH - Neurons/ultrastructure MH - *Software PMC - PMC3072555 DCOM- 20110915 LR - 20231204 DP - 2011 Apr 15 DEP - 20110223 AB - UNLABELLED: There is a strong and growing need in the biology research community for accurate, automated image analysis. Here, we describe CellProfiler 2.0, which has been engineered to meet the needs of its growing user base. It is more robust and user friendly, with new algorithms and features to facilitate high-throughput work. ImageJ plugins can now be run within a CellProfiler pipeline. AVAILABILITY AND IMPLEMENTATION: CellProfiler 2.0 is free and open source, available at http://www.cellprofiler.org under the GPL v. 2 license. It is available as a packaged application for Macintosh OS X and Microsoft Windows and can be compiled for Linux. CONTACT: anne@broadinstitute.org SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.