HLMA: Human Muscle Ageing Cell Atlas

Muscle atrophy and frailty are common manifestations of sarcopenia and are critical contributors to morbidity and mortality in the elderly. Deciphering the molecular mechanisms underlying sarcopenia has major implications for understanding human ageing. Yet progress has been slow, in part due to the complexity of characterising skeletal muscle niche heterogeneity (with myofibres being the most abundant) and of obtaining well-characterized human samples. Here, we have generated a single-cell/single-nucleus transcriptomic and chromatin accessibility map of human limb skeletal muscles encompassing over 387,000 cells/nuclei from individuals ranging from 15 to 99 years of age with distinct fitness and frailty levels.

Release at 2024-04-22

Lai, Y., Ramírez-Pardo, I., Isern, J., An, J., Perdiguero, E., Serrano, A. L., ... & Esteban, M. A. (2024). Multimodal cell atlas of the ageing human skeletal muscle. Nature, 1-11. DOI: 10.1038/s41586-024-07348-6