CBMSTA: A spatial transcriptome atlas of the mammalian whole cerebella

Recent discoveries about the molecular heterogeneity of the cerebellar cortex suggest the existence of functionally divergent subclasses of anatomically defined cell types. Using spatial transcriptome and single-nucleus RNA-seq analysis, we mapped 3D transcriptomic atlases of the whole cerebellum of mice, marmosets, and macaques at the single-cell resolution. Comparative analysis revealed specific cell types, cell localizations, and intra-cerebellum molecular heterogeneity across species. A comprehensive database generated from this study will expand the acknowledgment of the mammalian cerebellum.

Release at 2024-09-27

Shijie Hao et al., Cross-species single-cell spatial transcriptomic atlases of the cerebellar cortex. Science 385, eado3927 (2024). DOI: 10.1126/science.ado3927