SCAtlas HCL: Single-cell atlas of human cell lines

The SCAtlas HCL database analyzed 23,089 cells from 40 human cancer cell lines and 2 normal human cell lines to construct single-cell transmutation maps and visualize the data, and explored transcriptomic and epigenetic heterogeneity within individual cancer cell lines, finding that transcriptomic heterogeneity is a common feature of different cancers. The molecular mechanism of the interaction between the transcriptome and the epigenome is revealed.

Release at 2023-12-09

Zhu, Q., Zhao, X., Zhang, Y. et al. Single cell multi-omics reveal intra-cell-line heterogeneity across human cancer cell lines. Nat Commun 14, 8170 (2023). DOI: 10.1038/s41467-023-43991-9