LISTA: LIver Spatio-Temporal Atlas

The LISTA (LIver Spatio-Temporal Atlas) database used Stereo-seq (Spatio-Temporal Enhanced REsolution Omics-sequencing) combined with single-cell RNA-sequencing and single-cell ATAC-sequencing to profile mouse liver homoeostasis and a time course of regeneration after partial hepatectomy. This integrative spatiotemporal analysis accurately resolves the transcriptomic and epigenetic gradients controlling the identity of all liver cell types and their molecular crosstalk in both homeostasis and regeneration.

Release at 2024-04-16

Xu, J., Guo, P., Hao, S., Shangguan, S., Shi, Q., Volpe, G., ... & Esteban, M. A. (2024). A spatiotemporal atlas of mouse liver homeostasis and regeneration. Nature Genetics, 1-17. DOI: 10.1038/s41588-024-01709-7