Graded Expression of IRF4 Coordinates Isotype Switching with Plasma Cell Differentiation
Source: NCBI BioProject (ID PRJNA99637)
Source: NCBI BioProject (ID PRJNA99637)
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Project name: Graded Expression of IRF4 Coordinates Isotype Switching with Plasma Cell Differentiation
Description: Determine irf4 target genes in mouse B cells undergoing LPS differentiation to plasma cells in vitro. Determine targets of IRF4 by overexpression in a human GCB cell line.Keywords: cell type comparison designOverall design: Mouse lymphochip arrays consisted of a reference pool vs mouse Irf4+/- and mouse Irf4-/- samples. Human lymphochip arrays consisted of non-transduced vs IRF-4-transduced human cell line Oci-Ly7. Design included biological repeats at each time point. Only data from sequence-verified features were published. The mouse lymphochip consists of 701 confirmed features.
Data type: Transcriptome or Gene expression
Sample scope: Multispecies
Relevance: Other
Organization: Louis M Staudt, Metabolism Branch, National Cancer Institute
Literatures
- PMID: 16919487
Release date: 2006-11-24
Last updated: 2006-11-21