Dystrophin-deficient and dystrophin and utrophin double-deficient mice crossed with mice with full-length hDMD genes
Source: NCBI BioProject (ID PRJNA99225)
Source: NCBI BioProject (ID PRJNA99225)
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Project name: Mus musculus
Description: Crossing of hDMD mice that contain the full-length 2.3 Mb hDMD gene were crossed with dystrophin-deficient mdx mice and dystrophin and utrophin double-deficient mdx x utrn-/- mice resulted in a full rescue of the dystrophic features of these mice, as concluded from histological analysis. Analysis on Affymetrix gene chips demonstrated that also expression profiles of the dystrophic mice were normalized by crossing with transgenic hDMD mice. This confirms the full functionality of the hDMD transgene in mice.Keywords: disease state analysisOverall design: RNA from gastrocnemius muscle from individual mice was hybridized to Affymetrix U74Av2
Data type: Transcriptome or Gene expression
Sample scope: Multiisolate
Relevance: ModelOrganism
Organization: Center for Human and Clinical Genetics, Leiden University Medical Center
Literatures
- PMID: 18083704
Release date: 2007-12-13
Last updated: 2007-01-18