Project name: Aspergillus fumigatus

Description: Invasive pulmonary aspergillosis(IPA) is a life-threatening lung disease of immunocompromised individuals. IPA is typically caused by Aspergillus fumigatus,a species of fungus with a tendency for infection of pulmonary blood vessels and bronchi. As a well-known complication, IPA is a leading cause of death forpatients with chronic granulomatous disease(CGD),a primary immunodeficiency disorder that increases a patient's susceptibility to severe infections caused by particular bacteria and fungi. Thus, it is very important to identify the pathogen and begin pathogen-directed therapy as soon as possible for CGD patients complicated by IPA. In this study, we report a case of IPA in a CGD infant in which the pathogen was quickly detected by bronchoalveolar lavage fluid (BALF) next-generation sequencing (mNGS) and treated with appropriate antifungal therapy. This report uses mNGs to clarify the etiology of IPA. Case details and clinical characteristics of IPA are summarized in order to improve disease outcomes and to reduce misdiagnosis.

Data type: metagenome

Sample scope: Monoisolate

Last updated: 2022-06-15