Targeted degradation of BRD9 reverses oncogenic gene expression in synovial sarcoma [RNA-seq]
Source: NCBI BioProject (ID PRJNA450466)
Source: NCBI BioProject (ID PRJNA450466)
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Project name: Targeted degradation of BRD9 reverses oncogenic gene expression in synovial sarcoma [RNA-seq]
Description: We used a CRISPR-based screening approach to identify functional vulnerabilities in pediatric sarcoma cell types, identifying BRD9 as an important dependency in synovial sarcoma cells.Overall design: RNA-seq in synovial cells treated with dBRD9A or DMSO for 6hrs, or the same cells expressing control (Renilla) or SS18-SSX1 specific shRNAs.
Data type: Transcriptome or Gene expression
Sample scope: Multiisolate
Relevance: Medical
Organization: Genetics, Trinity College Dublin
Literatures
- PMID: 30431433
Last updated: 2018-04-16