5hmC dynamically correlated with enhancer's activities during hES-to-Pancreatic endoderm cell differentiation (CMS)
Source: NCBI BioProject (ID PRJNA383584)
Source: NCBI BioProject (ID PRJNA383584)
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Project name: Homo sapiens
Description: We generated 5hmC, WGBS and RNAseq of the cells in 5 stages during hES-to-pancreatic endoderm cell differantiation, and investigated the 5hmC correlation with 4 histones (H3K4me1, H3K4me3, H3K27ac and H3K27me3) during this process. Our results showed that 5hmC is dynamically correlate with enhancers' activities.Overall design: Purpose: Determine the roles of 5hmC during hES to pancreatic endoderm cell differentiation process. The whole genome bisulfite sequencing, CMS-IP, ATAC-seq and RNAseq for the 5 stages (ES,DE,GT,FG,PE) have been sequenced.
Data type: Epigenomics
Sample scope: Multiisolate
Relevance: Medical
Organization: Deqiang Sun, CEDP, Texas A&M U Health Science Center
Literatures
- PMID: 29394393
Last updated: 2017-04-19