Project name: Micro-Obes - Human Intestinal Tract Metagenomes

Description: MicroObes (Human Intestinal Microbiome in Obesity and Nutritional Transition - Sino-French initiative) is a project funded by the French National Agency for Research, carried out by a consortium of 3 institutions and associated to a partner project, MetaGUT in China. It focuses on the human intestinal microbiota, as it may be influenced by nutritional transition and the metabolic status of its human host with special emphasis on obesity and weight loss. MicroObes implements a metagenomics approach in order to :Sequence the repertoire of dominant genes of the human intestinal microbiota Apply high throughput metagenomic profiling to cohorts of patients included in concerted nutritional studies in China and France Identify functions of bacteria-host crosstalk with relevance in energy harvest from food. Sequences were obtained from stool samples of human volunteers enrolled in a clinical trial with controlled nutritional transition (for more details, see : http://www.inra.fr/micro_obes_eng/mise_en_oeuvre_et_avancement/soumission_de_sequences_metagenomiques).Total DNA was prepared from the samples, cloned in E. coli and randomly sequenced.This data is released as a community resource under the terms of the Fort Lauderdale agreement, for details see :<Ahref="http://www.wellcome.ac.uk/stellent/groups/corporatesite/@policy_communications/documents/web_document/wtd003207.pdf">http://www.wellcome.ac.uk/stellent/groups/corporatesite/@policy_communications/documents/web_document/wtd003207.pdf<Ahref="http://www.genome.gov/Pages/Research/WellcomeReport0303.pdf">http://www.genome.gov/Pages/Research/WellcomeReport0303.pdf

Last updated: 2008-11-18