Ablation of Pten and Smad4 leads to metastatic lung carcinoma in a murine model.
Source: NCBI BioProject (ID PRJNA203655)
Source: NCBI BioProject (ID PRJNA203655)
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Project name: Mus musculus
Description: Lung cancer is the leading cause of cancer related death in both men and women in the United States. Recently, Smad4 was discovered to be common somatic alteration in human squamous cell lung cancer. Our goal was to delineate the role of Smad4 in lung cancer. We have shown for the first time that the ablation of Pten and Smad4 in the murine airway epithelium harbors a metastatic proximal adeno-squamous lung cancer.Overall design: knockout group (PTENd/d and SMAD4d/d) and control group
Data type: Transcriptome or Gene expression
Sample scope: Multiisolate
Relevance: ModelOrganism
Organization: Biostatistics, Ducan Cancer Center, Baylor College of Medicine
Literatures
- PMID: 25753424
Last updated: 2013-05-20