Project name: Mus musculus

Description: In this study, we examined C57BL/6J and AJ mice who received either sham surgery or cholestatic intestinal injury.Mice were anesthetized by inhaled isoflurane anesthesia. The abdomen was clipped and then prepared in sterile fashion with 70% ethyl-ethanol followed by betadine. A transverse upper abdominal incision was performed. The CBD was dissected away from the portal vein and was ligated near its junction with the duodenum using aneurysm clips engineered with a precisely standardized opening/closing mechanism. The abdominal wall was then closed in a two-layer fashion using absorbable sutures. Sham-operated mice were treated identically but without dissection or ligation of the CBD.Overall design: Male AJ and C57BL6J mice, 8 weeks of age, were randomly assigned to surgery or sham (n=3 microarrays per strain/condition).

Data type: Transcriptome or Gene expression

Sample scope: Multiisolate

Relevance: ModelOrganism

Last updated: 2013-05-20