A hypomorphic Lsd1 allele results in heart development defects in mice.
Source: NCBI BioProject (ID PRJNA194618)
Source: NCBI BioProject (ID PRJNA194618)
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Project name: Mus musculus
Description: Microarray characterization of Lsd1 knock-outs compared to littermate controlsMicroarrays were employed to identify transcripts that were differentially modulated in the hearts of wild-type and Lsd1-hypomorphic late-stage embryos.Overall design: Late-stage embryonic hearts were isolated from wild-type and Lsd1-hypomorphic hearts, in order to isolate RNA for hybridization on Affymetrix microarrays. We sought to identify gene products that are differentially regulated between the two genotypes, in order to explain the observed ventricular septal defects in the hypomorphic animals.
Data type: Transcriptome or Gene expression
Sample scope: Multiisolate
Relevance: ModelOrganism
Organization: Novartis Institutes for Biomedical Research
Last updated: 2013-03-28