Transcriptome profiling of T84 colorectal carcinoma cells treated with receptor guanylyl cyclace C agonist (stable toxin)
Source: NCBI BioProject (ID PRJNA194541)
Source: NCBI BioProject (ID PRJNA194541)
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Project name: Homo sapiens
Description: Receptor guanylyl cyclase C (GC-C) is expressed in the intestinal epithelia and plays a key role in intestinal physiology. Activation of GC-C by its ligands has been shown to regulate proliferation and differentiation of enterocytes along the crypt-villus axis. This study aims to identify genes regulated by GC-C activation and elevation of cGMP in colorectal carcinoma cells. This will help understand the molecular targets and biological pathways regulated by GC-C to bring about cancer cell cytostasis.Overall design: ST (Cy5) Vs. Control (Cy3), ST (Cy5) Vs. Control (Cy3)
Data type: Transcriptome or Gene expression
Sample scope: Multiisolate
Relevance: Medical
Organization: Molecular Reproduction, Development and Genetics, Indian Institute of Science
Literatures
- PMID: 24217248
Last updated: 2013-03-27