ChIP-DSL H20K promoter array from human gastric cancer cells MKN28 with Sox2 overexpression
Source: NCBI BioProject (ID PRJNA193701)
Source: NCBI BioProject (ID PRJNA193701)
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Project name: Homo sapiens
Description: The transcription factor Sox2 inhibits human gastric cancer growth and activates Sox2-related tumor surpressive genes in human gastric cancer cells. Conditional Sox2-overexpression in cells with a low Sox2 level demonstrated that the Sox2-regulated tumor surpressive genes demand on an enhanced Sox2 activity for better expression to work in human gastric cancer.Chromatin immunoprecipitation (ChIP) of Sox2 together with chromatin profiling by ChIP-on-chip analysis demonstrated that Sox2 directly activates the chromatin at promoters or putative enhancers of Sox2 target genes.Overall design: Transcription factor Sox2 promoter array in MKN28 cells with Sox2 overexpression.
Data type: Epigenomics
Sample scope: Multiisolate
Relevance: Medical
Organization: State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, Fourth Military Medical University
Last updated: 2013-03-22