NAC, Tiron and Trolox impair GBM tumorigenic cell survival by mechanisms independent from antioxidant activity
Source: NCBI BioProject (ID PRJNA188652)
Source: NCBI BioProject (ID PRJNA188652)
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Project name: Homo sapiens
Description: The aim of this study is to determine if, using antioxidant drugs, it is possible to interfere with the proliferative capabilities of the human glioblastoma (GBM) tumor-initiating cells (TICs).Overall design: To establish which cellular processes are activated in GBM TICs by the antioxidants NAC, Tiron and Trolox, we generated and analyzed the gene expression profiles after treatment with these compounds and with H2O and EtOH (vehicles).
Data type: Transcriptome or Gene expression
Sample scope: Multiisolate
Relevance: Medical
Organization: S.S. Biofisica e Citometria, IRCCS AOU San Martino – IST, Genova
Literatures
- PMID: 24587218
Last updated: 2013-02-05