Eye imaginal disc expressing transgenic human proinsulin in Drosophila eye under regulation of GMR-GAL4
Source: NCBI BioProject (ID PRJNA184672)
Source: NCBI BioProject (ID PRJNA184672)
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Project name: Drosophila melanogaster
Description: We used microarrays to detail the global program of gene expression in response to expression of either mutant (C96Y) or wild-type human proinsulin and identified distinct classes of up-regulated genes. Results provides insight into the molecular mechanisms underlying a form of neonatal diabetes.Overall design: Drosophila eye imaginal discs were selected at the wandering stage of 3rd instar larval development for RNA extraction and hybridization on Affymetrix microarrays.
Data type: Transcriptome or Gene expression
Sample scope: Multiisolate
Relevance: ModelOrganism
Organization: Medicine, The University of Chicago
Literatures
- PMID: 24281154
Last updated: 2012-12-22