Methylomic analysis identifies the involvement of migration and adhesion genes in the ageing of primary haematopoietic stem cells
Source: NCBI BioProject (ID PRJNA177844)
Source: NCBI BioProject (ID PRJNA177844)
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Project name: Mus musculus
Description: we utilize Nano-MeDIP-seq for the analysis of the LT-HSC methylome and, for the first time, simultaneously interrogate the methylome and transcriptome of a homogeneous population of primary murine HSCs, in order to define the underlying causes of changes in HSC functionality during normal ageing.Overall design: We isolated and phenotyped primary LT-HSCs from young, middle-aged and old mice and subjected them to comprehensive methylome (MeDIP-seq) and transcriptome (RNA-seq) analysis.
Data type: Other
Sample scope: Multiisolate
Relevance: ModelOrganism
Organization: UCL Cancer Institute
Literatures
- PMID: 23949429
Last updated: 2012-10-17