Hrp3 controls nucleosome positioning to suppress non-coding transcription in eu- and heterochromatin [MNase-Seq]
Source: NCBI BioProject (ID PRJNA174085)
Source: NCBI BioProject (ID PRJNA174085)
0 0
Project name: Schizosaccharomyces pombe
Description: We report that the Schizosaccharomyces pombe CHD remodeler, Hrp3, is a global regulator that drives higher-order chromatin structure and genomic stability. The loss of Hrp3 resulted in nucleosome perturbation across the chromosome, and the production of antisense transcripts in the hrp3∆ cells emphasized the importance of nucleosome architecture for proper transcriptionOverall design: Examination of nucleosome positions in wild-type and mutants using the MNase-seq method
Data type: Epigenomics
Sample scope: Multiisolate
Relevance: ModelOrganism
Organization: Korea Advanced Institute of Science and Technology
Literatures
- PMID: 22990236
Last updated: 2012-08-29