The RALA pathway can maintain the proliferation of KRAS- and BRAF-mutated cancer cells
Source: NCBI BioProject (ID PRJNA171925)
Source: NCBI BioProject (ID PRJNA171925)
0 0
Project name: Homo sapiens
Description: By silencing of RALA, a downstream member of the RAS signal transduction pathway, we aimed to determine whether genes downstream of a mutated KRAS (codon 12 or 13) or a mutated BRAF can have significant functions in colorectal cancer carcinogenesis.Overall design: RALA was silenced in three colorectal cancer cell lines (SW480, HCT116 and HT29). Effects were normalized to mock-transfected cells and the effects of scramble siRNA were excluded.SW480, HCT116 and HT29 cell lines were treated with the PI3K inhibitor LY294002 or DMSO.
Data type: Transcriptome or Gene expression
Sample scope: Multiisolate
Relevance: Medical
Organization: Hungarian Academy of Sciences
Literatures
- PMID: 26033452
Last updated: 2012-08-02