Dnmt3a protects active chromosome domains against cancer-associated hypomethylation
Source: NCBI BioProject (ID PRJNA168371)
Source: NCBI BioProject (ID PRJNA168371)
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Project name: Mus musculus
Description: The results of the study uncover conserved features of cancer methylomes and provide a mechanistic explanation for the tumor-promoting effects of Dnmt3a mutations.Overall design: Whole genome methylation analysis of Mus musculus. Five samples were analyzed, one control sample containing normal healthy lung tissue, two samples containing big (WTB) or small (WTS) Dnmt3a WT tumors, two samples containing big (KOB) or small (KOS) Dnmt3a knock-out tumors
Data type: Epigenomics
Sample scope: Multiisolate
Relevance: ModelOrganism
Organization: German Center for Cancer Research
Literatures
- PMID: 23284304
Last updated: 2012-06-12