Project name: Mus musculus

Description: Genetic disruption of thioredoxin reductase 1 protects against acetaminophen (APAP) toxicity.To determine the role of the thioredoxin system on xenobiotic metabolism we challeneged wildtype and txnrd1liver-null mice with acetaminophen.Overall design: Adult male wildtype and txnrd1 liver-null mice (C57BL6/J) were treated with either saline (PBS) or 100mg/kg APAP. Liver RNA was harvested eight hours after challenge and processed for microarray analysis.Comparison of 2 treatment conditions in 2 genotypes, biological replicates in triplicate.

Data type: Transcriptome or Gene expression

Sample scope: Multiisolate

Relevance: ModelOrganism

Last updated: 2012-05-09