A novel miRNA produced during lytic HSV-1 infection is important for efficient replication in tissue culture.
Source: NCBI BioProject (ID PRJNA162879)
Source: NCBI BioProject (ID PRJNA162879)
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Project name: Homo sapiens
Description: We report a HSV-1 encoded miRNA present during lytic infection that influences replication efficiency in a tissue culture model. miRNAs were identified using high-throughput sequencing of HSV-1 infected epithelial cells. Functional assays were performed by mutating the miRNA coding region and testing grow of the mutant in vitro.Overall design: Construction of a miRNA library and sequencing to reveal novel viral miRNAs from lytically infected cells
Data type: Transcriptome or Gene expression
Sample scope: Monoisolate
Relevance: Medical
Organization: Burch Lab, Infectious Diseases, Wadsworth Center/ SUNY Albany/ Berkshire School
Release date: 2012-05-08
Last updated: 2012-05-02