Reversal of Aberrant Cancer Methylome and Transcriptome upon Direct Reprogramming of Lung Cancer Cells [Expression]
Source: NCBI BioProject (ID PRJNA155695)
Source: NCBI BioProject (ID PRJNA155695)
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Project name: Homo sapiens
Description: Non-small cell lung cancer cell (NSCLC) lines were reprogrammed with Yamanaka's cocktail and their methylome and transcriptome were studied and characterized.Overall design: We compared reprogrammed cells to their respective parent (2 NSCLC and 1 human lung fetal fibroblast) and used H1 as a positive control for pluripotency characteristics. The in vitro differentiated cells were also compared to the reprogrammed cells. All samples have biological triplicates except for differentiated cells.
Data type: Transcriptome or Gene expression
Sample scope: Multiisolate
Relevance: Medical
Organization: Stainier Lab, Developmental Genetics, Max Planck Institute For Heart and Lung Research
Literatures
- PMID: 22912920
Last updated: 2012-02-17