Astrocyte elevated gene-1 (AEG-1) promotes hepatocarcinogenesis: novel insights from a mouse model
Source: NCBI BioProject (ID PRJNA151219)
Source: NCBI BioProject (ID PRJNA151219)
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Project name: Mus musculus
Description: Astrocyte elevated gene-1 (AEG-1) as a positive inducer of hepatocellular carcinoma (HCC). Transgenic mice with hepatocyte-specific expression of AEG-1 were challenged with N-nitrosodiethylamine (DEN) and developed multinodular HCC with steatotic features. Thus, we have identified the follwoing AEG-1 functions: induction of steatosis, inhibition of senescence and activation of coagulation pathway to augment an aggressive hepatocarcinogenic phenotype.Overall design: Transgenic Mice liver tumors compared against WT mice liver tumors.
Data type: Transcriptome or Gene expression
Sample scope: Multiisolate
Relevance: ModelOrganism
Organization: VCU Institute of Molecular Medicine, Department of Human and Molecular Genetics, Virginia Commonwealth University
Literatures
- PMID: 22689379
Last updated: 2011-12-22