Mtb-mediated host transcriptional reponse is strain-specific
Source: NCBI BioProject (ID PRJNA145429)
Source: NCBI BioProject (ID PRJNA145429)
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Project name: Mus musculus
Description: CDC1551 induced more vigorous immune response in murine bone marrow derived macrophage (BMM). In contrast, in HN878-infected cells, host transcriptional response was delayed but lasted longer.HN878 induced more genes involved in host lipid metabolism than CDC1551 did.Overall design: Murine bone marrow derived macrophages were infected with M. tuberculosis CDC1551 or HN878 up to 24 h. Total RNA was processed for microarray and global gene expression was read.
Data type: Transcriptome or Gene expression
Sample scope: Multiisolate
Relevance: ModelOrganism
Organization: Public Health Research Institute, University of Medicine and Dentistry of New Jersey
Literatures
- PMID: 22280836
Release date: 2011-08-30
Last updated: 2011-08-29