FOXM1 Orchestrates a Global Methylation Signature that Mimics the Cancer Epigenome
Source: NCBI BioProject (ID PRJNA145189)
Source: NCBI BioProject (ID PRJNA145189)
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Project name: Homo sapiens
Description: Aberrant upregulation of a single oncogene FOXM1 in primary normal human oral epithelial cells orchestrated a cancer-like methylome landscapeThis study have identified a unique FOXM1-induced epigenetic signature which may have potentials as biomarkers for early oral cancer screening, diagnostic and/or therapeutic interventionsOverall design: Comparisons of primary human normal oral keratinocytes transduced with either EGFP (control) or FOXM1B and a head and neck squamous cell carcinoma cell line SCC15
Data type: Epigenomics
Sample scope: Multiisolate
Relevance: Medical
Organization: Head & Neck Cancer Unit, Centre for Clinical & Diagnostic Oral Sciences, Queen Mary University of London
Literatures
- PMID: 22461910
Release date: 2012-04-19
Last updated: 2011-08-30