Expression data from Notch-activated CD34+CD45RA-Lin- hematopoietic progenitor cells (HPCs) transduced with nuclear-trapped AF1q/MLLT11 (A2M)
Source: NCBI BioProject (ID PRJNA141477)
Source: NCBI BioProject (ID PRJNA141477)
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Project name: Homo sapiens
Description: We used microarrays to examine the impact of AF1q/MLLT11 on the gene expression profile of Notch-activated CD34+CD45RA-Lin- HPCs isolated from umbilical cord bloodCD34+CD45RA-Lin- HPCs correspond to early multipotent progenitors. A2M is a nuclear mutant derivative of AF1q/MLLT11Overall design: CD34+CD45RA-Lin- HPCs were FACS-sorted, exposed to A2M or control vectors, sorted again based on GFP expression, and cultured for 72 hrs with graded doses of plastic-immobilized Notch ligand Delta1ext-IgG
Data type: Transcriptome or Gene expression
Sample scope: Multiisolate
Relevance: Medical
Organization: biostatistique/bioinformatique, Institut Universitaire d'Hématologie
Release date: 2011-05-26
Last updated: 2011-05-25