Spatial segregation of BMP/Smad signaling affects osteoblast differentiation in C2C12 cells
Source: NCBI BioProject (ID PRJNA140215)

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Project name: Mus musculus
Description: Analysis of BMP-2 induced gene expression of C2C12 cells treated with the endocytosis inhibitor dynasore to identify gene expression profiles which are sensitive to endocytosis inhibition.Our data highlight the importance of endocytosis for transmission of an extracellular BMP-2 signal into the nucleus to activate a transcriptional gene networkOverall design: Total RNA obtained from C2C12 cells stimulated with BMP-2 together with the endocytosis inhibitor dynasore or DMSO as control compared to unstimulated cells treated with dynasore or DMSO alone.
Data type: Transcriptome or Gene expression
Sample scope: Multiisolate
Relevance: ModelOrganism
Organization: Knaus lab, Institut für Chemie und Biochemie, Freie Universität
Literatures
  1. PMID: 21998639
Release date: 2012-02-16
Last updated: 2011-05-18