The addition of chromosome 8 leads to characteristic dysregulation of gene expression on all chromosome and transformed-associated phenotypes - Project - Data resources

PRJNA139721

The addition of chromosome 8 leads to characteristic dysregulation of gene expression on all chromosome and transformed-associated phenotypes
Source: NCBI BioProject (ID PRJNA139721)

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Project name: Homo sapiens

Description: To examain effects of trisomy 8 on gene expression in normal human cells, we have employed whole genome microarray expression profiling. To study the effects of aneuploidy in normal human cells, we generated cells which are artificially trisomic chromosome 8 (trisomy 8) using human primary fibroblast cells by microcell-mediated chromosome transfer (HE35tri8 clones).Overall design: Gene expression in trisomy 8 clones (HE35tri8-1, 2 and3) and euploid clones (HE35-1, 2 and 4). Three independent experiments were performed at each clone.

Data type: Transcriptome or Gene expression

Sample scope: Multiisolate

Relevance: Medical

Organization: Radiation Biology, Medicine, Kyoto University

Literatures

PMID: 21980425

Last updated: 2011-03-21