Project name: Mus musculus

Description: The principal factors that lead to proliferation and pluripotency in embryonic stem cells (ESCs) have been vigorously investigated. However, the global network of factors and their full signaling cascade is still unclear. In this study, we found that ECAT11 (L1td1) is one of the ESC-associated transcripts harboring a truncated fragment of ORF-1, a component of the L1 retrotransposable element. We generated an ECAT11 knock-in mouse by replacing its coding region with green fluorescent protein. DNA microarray analyses revealed that ECAT11EGFP/EGFP ESCs showed similar global gene expression profiles as the wild type ESCsOverall design: Samples from wild type ESCs and ECAT11EGFP/EGFP ESCs

Data type: Transcriptome or Gene expression

Sample scope: Multiisolate

Relevance: ModelOrganism

Release date: 2011-05-27

Last updated: 2011-03-24