Project name: Mus musculus

Description: These experiments aim determine the effects of Pten signaling in fibroblasts on gene expression in other cell compartments in the mammary gland.Overall design: To achieve this, we used a genetic model in which the tumor suppressor gene Pten was specifically inactivated in stromal fibroblats. We then isolated fibroblasts, epithelial cells and endothelial cells from the mammary glands of mice with either wild type or Pten null fibroblasts. Comparisons were made between wild type and Pten counterparts, not between the various cell types.

Data type: Transcriptome or Gene expression

Sample scope: Multiisolate

Relevance: ModelOrganism

Release date: 2011-12-18

Last updated: 2010-10-04