The effect of IFNα on human CD8 T cells_with other concomitant signals
Source: NCBI BioProject (ID PRJNA123599)
Source: NCBI BioProject (ID PRJNA123599)
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Project name: Homo sapiens
Description: IFN alpha mediated gene expression pattern. The effect of IFN alpha on human CD8 T cells responding to antigen (signal 1) and costimulatory signals (signal 2) provided by beads coated with anti-CD3 and anti-CD28 mAbs.This analysis examined the effects of IFN alpha on human CD8 T cells responding to antigen (signal 1) and costimulatory signals (signal 2) provided by beads coated with anti-CD3 and anti-CD28 mAbs. Magnetically sorted untouched CD8+CD45R0- T cells from three different donors were unstimulated or stimulated with IFNa2b or with anti-CD3/CD28 Beads alone or along with IFNa2b or IFNa5 for 48 hours. Individual mRNA samples were analyzed using HG-U133A 2.0 array gene chips.Keywords: Gene expression analysis after different stimulationOverall design: Magnetically sorted untouched CD8+CD45R0-T cells from three different donors (named A, B and C) unstimulated or stimulated with IFN alpha 2b or with anti-CD3/CD28 beads alone or along with IFN alpha 2b or IFN alpha 5 for 48 hours.
Data type: Transcriptome or Gene expression
Sample scope: Multiisolate
Relevance: Medical
Organization: 3.03. Clinic immunology, Hepathology and Gene Therapy, Center for applied medical research
Literatures
- PMID: 21108462
Release date: 2010-07-23
Last updated: 2009-07-24