Integrated bioinformatic and wet-lab approach to identify potential oncogenic networks in neuroblastoma: MEIS1
Source: NCBI BioProject (ID PRJNA123295)
Source: NCBI BioProject (ID PRJNA123295)
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Project name: Homo sapiens
Description: The pediatric tumor neuroblastoma is the second cause of cancer-related death in children. Although several recurrent gene aberrations have been found, the main signaling networks in the neuroblastoma cell, that can give important clues for more specific, more efficient treatment, is still unknown. Here we demonstrate an analysis of the MEIS1 pathway in neuroblastic tumors. It suggests important regulatory connections to tumor differentiation, cell cycle, and cell death.Overall design: Time-course experiment of MEIS1-shRNA induction, with 5 timepoints.
Data type: Transcriptome or Gene expression
Sample scope: Multiisolate
Relevance: Medical
Organization: Department of Oncogenomics, Academic Medical Centre, University of Amsterdam
Last updated: 2009-08-26