Project name: Homo sapiens

Description: AEBP1 has been identified as a transcriptional repressor playing asignificant role in adipogenesis. Recently, we have found that AEBP1 isspecifically upregulated in primary glioblastoma. We have used genesilencing to identify genes perturbed upon AEBP1 downregulation andChIP-chip technique to identify its genomic targets of binding andregulation to understand the un-annotated/undescribed role of thistranscription factor in gliomagenesis.Overall design: Cells either mock silenced or silenced using siRNA against AEBP1 were harvested at 46hrs post transfection. Gene expression was profiled for control and AEBP1 silenced cells.comparison of AEBP1/Rabbit IgG/ Glial cells

Data type: Other

Sample scope: Multiisolate

Relevance: Medical

Last updated: 2009-11-04