Punctual ablation of Foxp3+ T cells unleashes an autoimmune lesion
Source: NCBI BioProject (ID PRJNA119423)
Source: NCBI BioProject (ID PRJNA119423)
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Project name: Mus musculus
Description: How do Treg cells control an autoimmune lesion? We depleted Foxp3+ Treg cells in autoimmune prone TCR transgenic BDC2.5 mice on the NOD backgroundKinetic of gene-expression changes in CD4 T cells isolated for pancreas and pancreas draining lymph node (PLN) of Foxp3-DTR.BDC2.5/NOD mice after Treg cell ablationKeywords: T cell activation/ differentiation after Treg depletion timecourseOverall design: CD4 T cells were isolated from pancreas and PLN at 0, 15 and 24 hours after diphtheria toxin application into 4-6 week old female Foxp3-DTR.BDC2.5/NOD transgenic mice
Data type: Transcriptome or Gene expression
Sample scope: Multiisolate
Relevance: ModelOrganism
Organization: CBDM, Microbiology and Immunobiology, Harvard Medical School
Release date: 2009-10-15
Last updated: 2009-09-16