Gene Expression Profiling in A549 Lung Cancer Cell Line Following siRNA Mediated Knock-down of ALDH1A1 and ALDH3A1 - Project - Data resources

PRJNA100867

Gene Expression Profiling in A549 Lung Cancer Cell Line Following siRNA Mediated Knock-down of ALDH1A1 and ALDH3A1
Source: NCBI BioProject (ID PRJNA100867)

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Project name: Homo sapiens

Description: Aldehyde dehydrogenase isozymes ALDH1A1 and ALDH3A1 are highly expressed in non small cell cell lung cancer. Neither the mechanism nor the biological significance for such over expression have been studied.We used microarrays to analyze changes in A549 lung cancer cell line in which ALDH activity was reduced using lentiviral mediated expression of siRNA against both isozymes (Lenti 1+3)Keywords: Gene Profiling after ALDH Knock DownOverall design: A549 lung cancer cell lines were transduced with lentiviral vectors containing specific siRNA sequences against ALDH1A1, ALDH3A1, both vectors (Lenti 1+3 cells), and against the green flourescent protein (GFP) gene (GFP cells, used as control).

Data type: Transcriptome or Gene expression

Sample scope: Multiisolate

Relevance: Medical

Organization: Microarray lab 103, Molecular Genetics and Microbiology, University of Florida

Release date: 2008-10-29

Last updated: 2007-06-06