Project name: Aspergillus fumigatus

Description: Aspergillus AtrR-family proteins are identified as a transcription factor involved in azole resistance. The A. fumigatus AtrR regulates expression of cyp51A and cdr1B, encoding a target enzyme in ergosterol biosynthesis pathway and ABC transporter related to azole resistance, respectively. To gain an insight into global regulation of the AtrR, RNA-seq analysis was conducted, in which 1) WT (Af293) and the atrR deletion mutant in response to azole treatment, and 2) WT (Af293), atrR, and srbA deletion mutants, were investigated.

Data type: Transcriptome or Gene expression

Sample scope: Multiisolate

Relevance: Medical

Release date: 2016-12-13

Last updated: 2016-11-08