Description: To explore the possible molecular mechanisms by which pyruvate oxidative phosphorylation affects club cell differentiation and airway inflammation, we performed both scRNA-seq and bulk RNA-seq on lung tissues from control-OVA and Mpc2CKO-OVA mice following OVA-induced airway inflammation. These data suggest that Cxcl17 expression is more sensitive to alterations in the pyruvate oxidative phosphorylation pathway, and its upregulation may be a key downstream effect of Mpc2 deletion in secretory epithelial cells.

Data type: Transcriptome or Gene expression

Sample scope: Monoisolate

Release date: 2025-11-14

Last updated: 2025-11-14

Data size: 199.04GB