Description: Background: Spaceflight is physically demanding and has negative effects on the bone formation of astronauts. Previous studies demonstrated that the human gut microbiota and lactobacillus rhamnosus GG (LGG) were affected by spaceflight. However, changes in the abundance of LGG whether influence the bone formation under spaceflight condition is unclear. Results: This study investigated the effects of LGG on simulated spaceflight-induced bone loss in hindlimb unloading (HU) mice. Bone formation of HU mice were affected by the gut microbiota, transplantation of the fecal microbiota from HU mice affects the bone formation in control mice and transplantation of the fecal microbiota from control mice protects the bone formation in HU mice. The LGG and simulated microgravity stimulated LGG (SMG) gavage protected the bone formation in HU mice. Conclusion: Our findings indicate that spaceflight adversely affects bone formation, and the LGG can protects spaceflight-induced bone loss.

Data type: Metabolome

Sample scope: Monoisolate

Release date: 2025-07-22

Last updated: 2025-07-22