Description: A more comprehensive understanding of the cellular and molecular pathology pathways of lupus nephritis fibrosis is essential for the accurate assessment of disease status and the development of novel therapeutic strategies for patients with LN. In this study, we employed advanced spatial transcriptome technique to elucidate the potential mechanism of renal fibrosis in mouse kidneys. We established single-cell spatial transcriptomics for LN and control kidneys and indicate that fibroblasts predominantly activate and proliferate in the inner medulla region within kidneys, and that a set of genes associated with fibrosis can be identified. A class of pro-fibrotic macrophage subtype, Lyz2 macrophage was identified that promote myofibroblast activation, and the molecular interplay mechanisms involved in this process were resolved. We conducted a simultaneous exploration of disease-induced alterations in gene expression within the glomerular region and identified potential novel targets.

Data type: Raw sequence reads

Sample scope: Multiisolate

Relevance: Other

Release date: 2025-11-27

Last updated: 2025-11-27

Data size: 3.38TB