Description: Gout, considered the most prevalent form of inflammatory arthritis worldwide, commonly affects the elderly. Research has demonstrated an inherent association between gut microbiota and gout. However, studies on the involvement of gut microbiota in the manifestation of gout during senescence remain scant. Hence, this study performed fecal microbiota transplantation in old or aged recipient mice using microbiota obtained from young donor mice. Fecal microbiota transplantation in young recipient mice using microbiota derived from old or aged donor mice was also undertaken. Subsequently, they were exposed to monosodium urate (MSU) crystal stimulation through intraperitoneal footpad administration or injection. Here, we found that the microbiota transplantation from young donors effectively alleviated the inflammatory response by inhibiting the NLRP3 inflammasome pathway and exerted beneficial effects on the uric acid metabolism of the old or aged recipient mice. However, young recipient mice that received the old or aged microbiota presented opposite results. Further in-depth research revealed that butyrate possesses dual effects of inhibiting inflammation in acute gout and reducing serum uric acid levels in aged mice. Our findings suggest that the "younger" gut microbiota positively impacts the gut microbiota structure and metabolism of the old or aged mice to prevent gout, potentially serving as a therapeutic target for senile gout-related conditions.

Data type: Genome sequencing; Metabolome

Sample scope: Multiisolate

Relevance: Medical

Release date: 2025-01-14

Last updated: 2025-01-14

Data size: 698.35MB