Description: Clear cell renal cell carcinoma (ccRCC) ranks the most prevalent urinary tumors. Molecular studies of genomics, transcriptomics, and epigenomics have greatly advanced the diagnosis and treatment. However, the hallmarks of extrachromosomal circular DNA are still unclear in ccRCC. In this study, we thoroughly explored the landscape of eccDNA in paired samples from nighty-nine ccRCC and compare with twenty-three other subtypes of RCCs. A strong correlation of eccDNA and oncogene transcription was identified. Meanwhile, multiple oncogenes carrying eccDNAs were detected from tumor samples. Of note, we also proposed an eccDNA driven immunology effects in late stage ccRCCs.

Data type: Raw sequence reads

Sample scope: Multiisolate

Release date: 2023-12-28

Last updated: 2023-12-28

Data size: 37.82TB