Description: Trisomy 21, or Down syndrome (DS), was the most frequent human autosomal chromosome aeuploidy, which would lead to multiple developmental disorders, especially for mental retardation in individuals. The presence of additional human chromosome 21 (Hsa21) could account for the pathological manifestations in DS. In this study, we analyzed the mRNA gene expression profile of DS derived amniocytes compared with normal, aiming to evaluate the relationship between candidate dysregulated Hsa21 genes and DS developmental phenotype.

Data type: Transcriptome or Gene expression

Sample scope: Multiisolate

Relevance: Medical

Release date: 2022-11-20

Last updated: 2022-11-20

Data size: 14.7GB