Description: The placenta is important for the fetal development in mammals. The stereo-seq is a rapidly developing method. In this study, we resolved the structure of human placenta villi at the first trimester using modified stereo-seq. The stereo-seq using PFA-fixed chorionic villi as input could capture specific and strong RNA signals. The main cell types in chorionic villi with classical markers were identified in their physiological position. The regulons were investigated and specific transcription factors in different cell types associated with their differentiation and functions. Finally, the viral receptors and drug transporters in villi were identified according to the pathway analysis. Our study broadens the application scope of stereo-seq, especially for loose tissues. Our trial provides an additional method to investigate the placenta structure, development, physiology and pathology.

Data type: Raw sequence reads

Sample scope: Monoisolate

Release date: 2024-09-14

Last updated: 2024-09-14

Data size: 1.08TB