Description: Children with cerebral palsy (CP) have been shown with a higher prevalence and severity of caries. Although multiple risk factors for caries in CP children have been studied. The function of microorganisms as a necessary condition for caries in CP should be further investigated. The supragingival plaque samples were collected from 55 CP children and 23 non-CP children to detect the supragingival plaque microbiota (SPM) in CP children by 16S rDNA sequencing. The difference of SPM was checked between CP children(CPCS) and non-CP one (NCPCS) with high severity of caries. Also, the SPM was analyzed in CP children with different degrees including caries-free (CPCF), mild to moderate (CPCM), and severe caries (CPCS). We found the top 15 most abundant species in all groups, significant enrichment of Fusobacterium nucleatum, Prevotella intermedia, Campylobacter rectus, Porphyromonas endodontalis, Catonella morbi, Alloprevotella tannerae, Parvimonas micra, Streptobacillus moniliformis, Porphyromonas canoris were found in CPCS. The suspected core cariogenic microbiota of CP children included Prevotella, Alloprevotella, Actinomyces, Catonella and Streptobacillus, while Capnocytophaga and Campylobacter are dental health-associated microbiota of CP children. The core correlation network of SPM in each group was also constructed. Our results showed that there was no significant difference in bacterial diversity between NCPCS and CPCS, but CPCS had a much simpler correlation network than NCPCS. In CP children, lower bacterial diversity in CPCM and CPCF showed simple correlation networks. Overall, the study showed the specific SPM characteristics of CP children with severe caries compared to non-CP control and revealed the correlation network of core SPM in CP children with different severity of caries.

Data type: Raw sequence reads; Metagenome

Sample scope: Environment

Release date: 2022-01-01

Last updated: 2021-11-22

Data size: 733.47MB