Description: The outbreak of the new human coronavirus 2019 (HCoV-19/SARS-CoV-2) has caused a pandemic of novel coronavirus disease (COVID-19). Great international efforts have been put into the development of prophylactic vaccines and neutralizing antibodies. However, a systematic profiling of dynamic changes of the patient’s B-cell receptor (BCR) repertoire after being infected by HCoV-19 is still lacking. Here, we report a comprehensive characterization of the dynamics of immunoglobin heavy chain (IGH) repertoire in COVID-19 patients. By using next-generation sequencing technology, we interrogated the landscape of patient’s immunological status over time, featured with dramatic changes of the IGH within the patients’ immune system undergone after symptoms onset. Althouh different patients have distinct immune responses to HCoV-19 infection, through clonotype overlap, lineage expansion and clonotype network analyses, we observed the higher clonotype overlap and substantial lineage expansion of COVID-19 patients during 2-3 weeks of illness, which is of great importance to B-cell immune responses. Meanwhile, for preferences of V gene usage during HCoV-19 infection, IGHV3-74 and IGHV4-34 and IGHV4-39 in COVID-19 patients showed more abundant than that of healthy controls. Overall, we present an immunological resource for HCoV-19 that could promote both therapeutic development and mechanistic research.

Data type: Raw sequence reads

Sample scope: Multiisolate

Release date: 2021-06-08

Last updated: 2020-06-08

Data size: 144.15GB