Depression of protective mechanisms against microörganisms in tumor-bearing mice and its restoration by adjuvants.
Gan, 1977/8;68(4):465-71.
Matsuo K, Nomoto K, Shimotori S, Takeya K
PMID: 99344
Abstract
Bacterial growth within 72 hr after an intravenous inoculation with Listeria monocytogenes was enhanced strikingly in the liver of mice, when viable cells of sarcoma-180 were injected subcutaneously into ddN, C3H/He, and BALB/c mice 5 hr before the inoculation. Such an enhanced bacterial growth appears to be attributable to a depressed ability of macrophages to digest engulfed bacteria. Pretreatments with zymosan, killed BCG, or viable BCG prevented such depression in tumor-bearing mice and increased the bactericidal activity in the liver of normal and tumor-bearing mice above the level of non-treated normal mice. Such adjuvants may be useful not only for augmentation of antitumor activity but also for augmentation of antimicrobial activity in tumor-bearing hosts.
MeSH terms
Adjuvants, Immunologic; Animals; BCG Vaccine; Bacteria; Cell Migration Inhibition; Female; Listeria monocytogenes; Listeriosis; Liver; Macrophages; Mice; Mycobacterium bovis; Sarcoma 180; Zymosan
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