Anticonvulsant action of a 1,5-benzodiazepine, clobazam, in reflex epilepsy.
Epilepsia, 1978/6;19(3):293-9.
Chapman AG, Horton RW, Meldrum BS
PMID: 98317
Impact factor: 6.74
Abstract
Clobazam, an anxiolytic 1,5-benzodiazepine, has been evaluated as an anticonvulsant in 2 animal models. In mice showing sound induced seizures, clobazam, 1--4 mg/kg, i.p., blocked seizure responses for 1--2 hr. In Senegalese baboons Papio papio showing photically induced myoclonus or seizures, clobazam, 2--12 mg/kg, i.v., totally prevented such responses for up to 6 hr. In baboons pretreated with allylglycine, 170--185 mg/kg, a similar but briefer protection was induced by clobazam. Neurological toxicity was not prominent (transient, slight nystagmus after clobazam, 2--6 mg/kg; muscular hypotonia after clobazam, 12 mg/kg). The possibility that 1,5-benzodiazepines are superior to 1,4-benzodiazepines in the therapy of epilepsy requires clinical investigation.
MeSH terms
Acoustic Stimulation; Animals; Anticonvulsants; Benzodiazepinones; Disease Models, Animal; Drug Evaluation, Preclinical; Electroencephalography; Epilepsies, Partial; Epilepsy; Glycine; Haplorhini; Mice; Papio; Photic Stimulation; Seizures
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